This community of Incarnate Word Sisters was founded by the congregation of Guadalajara in 1912, in response to the bishop's request. Six members formed the first community in Mascota. Beginning in 1914, the Sisters suffered from persecutions of varied intensity. Consequently, in 1920 the Sisters moved to Guadalajara, then to San Andres Tuxtla, and finally to the State of Puebla.

By 1930, the community had managed to save enough money to purchase some land in Míxcoac. Even after that, religious persecution continued to threaten all religious institutes throughout México. Though the Sisters lived in fear and endured many difficulties, they continued to receive vocations. From 1934 to 1938 they again had to close their school. They began to teach privately, and worked in whatever way they could to support themselves.

In January, 1946, seven Sisters went to Tlapacoyan to open a school. They were supported in part by the Bishop. Fifteen years later, this community of Tlapacoyan joined the Generalate of México City.

The Golden Jubilee of this community was joyfully celebrated in 1962. In 1981, they opened a school in Michoacán; and another in Mérida, Yucatán in 1987.