In the year 1903, France suffered anew, a persecution against religious congregations. The house of Belmont was one of the first ones to be attacked. Three Religious, Mother Marie Claire de Jésus Dubois, Mother Marie de Gonzaga Poullet, and Mother Marie de Jésus Chassagne, requested permission to continue living their religious life in one of the houses of the Incarnate Word, already existing in America. They arrived in San Antonio, Texas, where the Sisters of Charity of the Incarnate Word offered them accommodations. Later on, Mother Claire de Jésus Dubois was assigned to the house of Corpus Christi. Mother Stanislaus accepted the invitation to take responsibility for a school in the city of Guadalajara and assigned Mother Claire de Jésus Dubois, Mother Marie de Gonzaga Poullet and Mother Marie de Jésus Chassagne for that mission.

The Sisters arrived in Guadalajara on December 9, 1903. Mother Claire de Jésus Dubois was named the Superior. The small Community received canonical approval on January 15, 1905, and gave thanks to Divine Providence who has always been admirable in all His works, and in a special way, in the foundation of this Community.

The House of Guadalajara made its first foundation in Tepic, Nayarit, in 1908, and M. Marie de Gonzaga Poullet was named Superior. Soon after, the Community opened a school. The School of the Incarnate Word, as well as the Community, enjoyed a great acceptance, calling it the Oasis Jaliciense of the Incarnate Word. In 1912, the House of Guadalajara received another request for a second foundation, this time in Mascota, Jalisco. Mother María Teresa Cruz de la Trinidad, and three Sisters, went joyfully to fulfill the mission the Incarnate Word was asking of them.

In 1914, when the Religious persecution began in México, the Convents and schools were closed and confiscated, and the Sisters could not wear habits. They were dispersed, and some went to their families; but seven Sisters remained in the Convent. The Sisters looked for security outside of México. In November, 1915, M. María of the Child Jesus requested permission to open a Convent of the Incarnate Word in Cuba.

On September 18, 1918, Mother Claire de Jésus Dubois died at the age of 55. The Community lost a very tender and dear mother, who left examples of a virtuous life. After blessing the Community, she promised that she would not abandon them, but would continue praying from Heaven for her beloved France, and for México, her second country. No one found herself worthy of taking the position left by Mother "Clarita." On March 29, 1919, after prayer and consultation, the elections for the new Superior took place. The result was that Mother María de Jesús Hernåndez, the first Mexican, was elected superior.

The religious persecution continued; and in 1925 the Community was dispersed again. In 1928 the Sisters suffered a search of their Convent, and the Superior, María de Jesús Hernåndez, and six other Sisters were taken by the police. They spent five days in prison, suffering painful works and humiliations. But they were consoled by God, Who never abandons us, in the person of Father Ramiro Camacho who, disguised, would take the Holy Eucharist to them, and the Sisters would spend some time in adoration before each one took the Host in Communion.

In 1935, when General Låzaro Cårdenas was elected President of México, religious persecution was intensified. He ordered that socialist teachings be imposed on all private schools, and that churches and convents be confiscated.

In 1936, the Sisters received the great news that the Cause for the Beatification of Venerable Mother Foundress, Jeanne Chézard de Matel, had been introduced in Rome. And in November of the same year, they received the translation of the life of their Venerable Mother into Spanish, made by Father Félix de Jésus Rougier, a Missionary of the Holy Spirit.

By 1941, the political situation began to change a little, and the community enjoyed a time of relative peace. Some aspirants join the community, and students came to the School.

In 1948, the Mothers from Lyon, France, requested three Sisters from the Community to open a house in Madrid, Spain. The Community of Guadalajara, which had always respected the Community of Lyon, could not refuse such a petition; and in spite of the painful separation, and the precarious economic situation of the Community, it was decided to send Sisters María Angela Ledesma, María de la Paz Jiménez, and María del Carmen de Alba, who left for Spain on July 27, 1949. These Mothers taught the community to share from their poverty.

By this time, the Community was in very difficult financial situation and in need of finding an adequate place for the school and the convent. In view of this, the Sisters courageously went out to look for benefactors, wherever the Spirit guided them to go. And in 1950, the Incarnate Word answered their prayer and efforts, granting them a new house in Chapalita, where the Motherhouse is located today.

On July 26, 1955, the Order of the Incarnate Word and Blessed Sacrament became officially constituted as a Congregation, with the other houses of Lyon, France, Spain, Guadalajara, and Querétaro. The Superior General was Mother Hermenegilda de Armendåiz Garcia from the Monastery of Lyon, France.

At the time of the death of Mother Hermenegilda in June of 1958, Mother Marie de la Encarnación Metz was elected Superior General for six years, and was reelected at the end of the six-year term.

In 1968, the "Celanese," a business from Ocotlån, Jalisco, requested Sisters to staff a school, a request which they responded to positively.

After Vatican Council II, the Bishops invited all Religious Communities to an authentic renewal of religious life. The Community received the help of Rev. Father Ignacio Gómez Ward, S.D.B. who suggested that they begin this renewal by updating the Constitutions according to the directives of Vatican Council II.

In 1969 another foundation took place in Cajititlån, Jalisco.

On September 15, 1970, the Holy See gave the approval for the Community of Guadalajara to form a new Generalate, with the following houses: Guadalajara, Querétaro, Cajititlån and Ocotlån; with Guadalajara being the Generalete, and keeping the same name and apostolic activity. Conscious of this great gift, they felt the responsibility to move on as a Congregation, and as heiresses of the seed of the Order planted by their French Mothers during the previous seventy-five years. The First General Chapter was called, with Mother María de la Paz Jiménez Campos elected as Superior General.

The community continued to grow and accepted invitations to staff many new schools and ministries, including:

• A new foundation was made in Tuxtla Gutierrez, Chiapas, with sisters dedicated to Pastoral work and Evangelization (1971)
• A new community was founded in Ribera de Guadalupe, Jalisco, to staff a Parochial School (1977)
• Colegio Matel was opened in Estación Juårez, Chiapas (August 26, 1984)
• The Instituto Matel was founded in Teocelo, Veracruz (1985)
• Tuxtla Gutiérrez, Chiapas, became the house of formation. (1988)
• A new foundation was made in San Martín Hidalgo, Jalisco (2003)