In 1903, Bishop Filemon Fierro of Tamaulipas asked the Brownsville monastery for Sisters to establish a new foundation in Tula, Tamaulipas. Mother Mary of the Sacred Heart of Jesus Hord, Mother Vincent Helena O'Herlihy, and Sister Theresa O'Keefe traveled by coach, train and horseback, arriving there on September 25, 1903. In 1906, unable to support themselves in Tula, they moved their foundation to Gómez Palacio. Soon new members joined them from both México and Ireland.

The next few years passed quietly until the time of Madero's Revolution in 1910. Gómez Palacio was continually under attack because it was in a central common ground for fighting. In September, 1914, the twenty-five Sisters took refuge in Arkansas in the U.S. for a time. Then they were invited to settle in Cuba where they opened schools in Cienfuegos, Cruces, Esperanza, Lajas and Trinidad.

In 1921, finding the weather very harsh in Cuba, and after several Sisters died there, the community decided to returned to Gómez Palacio where the Revolution had quieted. They reopened their school and began working to restore their convent. Sadly, the persecution began again in 1926. During this time the Sisters' property was confiscated, some were imprisoned and some even died as martyrs. Since foreigners were not welcome in México, the Irish Sisters and those from the United States left México. Some were accepted by Archbishop Schrembs of Cleveland, Ohio. Once the persecution in México subsided, some of the Sisters of the Gómez Palacio community returned there. In 1981 the Sisters opened new foundations in Tepehuanes, Durango, and in 1984, in Yahualica, Jalisco. The Sisters have continued their ministry until the present.